Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups

Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups

Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions. Herein we explored whether urinary proteomic biomarkers specific for different forms of arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inf...

Biomarkers of Inflammatory Arthritis and Proteomics

COUNTING DISTINCT FUZZY SUBGROUPS OF SOME RANK-3 ABELIAN GROUPS

In this paper we classify fuzzy subgroups of a rank-3 abelian group $G = mathbb{Z}_{p^n} + mathbb{Z}_p + mathbb{Z}_p$ for any fixed prime $p$ and any positive integer $n$, using a natural equivalence relation given in cite{mur:01}. We present and prove explicit polynomial formulae for the number of (i) subgroups, (ii) maximal chains of subgroups, (iii) distinct fuzzy subgroups, (iv) non-isomorp...

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of pediatric GBM. Here, we show that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are...

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes

The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular differences linked to the protracted disease course of ACC and metastases that form 5 or more years after diagnosis, detailed RNA-sequencing (RNA-seq) analysis was performed on 68 ACC...